Article
Teratogen-induced, dietary and genetic models of congenital diaphragmatic hernia share a common mechanism of pathogenesis.
The American journal of pathology - 1 Nov 2006
Clugston Robin D, Klattig Jürgen, Englert Chistoph, Clagett-Dame Margaret, Martinovic Jelena, Benachi Alexandra, Greer John J
Abstract excerpt
Congenital diaphragmatic hernia (CDH) is a frequently occurring, major congenital abnormality that has high mortality and significant morbidity in survivors. Currently, the pathogenesis of CDH is poorly understood. In this study, we have compared the anatomical characteristics of diaphragm defects in the well-described nitrofen model with the pathogenesis of CDH in vitamin A-deficient rats and wt1 null-mutant...
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