Article
Prenatal treprostinil reduces the pulmonary hypertension phenotype in the rat model of congenital diaphragmatic hernia.
EBioMedicine - 1 Jul 2022
De Bie Felix Rafael, Halline Christopher Gates, Kotzur Travis, Hayes Kevin, Rouse Christopher Copeland, Chang Jonathan, Larson Abby Christine, Khan Sameer Ahmad, Spina Ashley, Tilden Samantha, Russo Francesca Maria, Hedrick Holly Lee, Deprest Jan, Partridge Emily Anne
Abstract excerpt
BACKGROUND: Persistent pulmonary hypertension (PH) causes significant mortality and morbidity in infants with congenital diaphragmatic hernia (CDH). Since pulmonary vascular abnormalities in CDH develop early during foetal development, we hypothesized that prenatal maternal administration of treprostinil, through its anti-remodelling effect, would improve the PH-phenotype in the nitrofen rat model of CDH....
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