Article
Mechanical compression causes lung hypoplasia in congenital diaphragmatic hernia with GATA4 genetic variants.
American journal of physiology. Lung cellular and molecular physiology - 1 Apr 2026
Pham Betty, Li Zhuowei, Luna Gidsela, Talaba Nicole, Zhang Na, Stokes Giangela M, Wienhold Mark, Xu Jinhao, Su Yujuan, Hernan Rebecca, Chung Wendy K, Sun Xin, McCulley David J
Abstract excerpt
Congenital diaphragmatic hernia (CDH) is a common and severe structural malformation in which the high rate of morbidity and mortality is caused by lung hypoplasia and pulmonary hypertension. The severity of lung and pulmonary vascular defects in patients with CDH is heterogeneous with both intrinsic defects during development and mechanical compression playing important roles. Genetic variants have been...
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