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The Role of PEDF in Reproductive Aging of the Ovary

8 Sept 2022

Abstract excerpt

Reproductive aging is characterized by a decline in ovarian function and in oocytes' quantity and quality. Pigment epithelium-derived factor (PEDF), a pivotal player in ovarian angiogenic and oxidative balance, was evaluated for its involvement in reproductive aging. Our work examines the initial stage of reproductive aging in women and mice, and the involvement of PEDF in the process. Granulosa cells from...

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PMID: 36142276
DOI: 10.3390/ijms231810359

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