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Article

In Silico Analysis of Novel circRNA-miRNA-mRNA Axis in BRAFV600E Melanoma: Implications for Primary to Metastasis Transformation and TIME Modulation.

The journal of gene medicine - 1 Jun 2025

Naik Hemangini, Choudhary Rajat, Konkimalla V Badireenath

Abstract excerpt

BACKGROUND: The BRAFV600E mutation drives metastatic transition by altering the tumor immune microenvironment (TIME) through transcriptional and post-transcriptional regulation. Recent studies identify circular RNA (circRNA) and micro-RNA (miRNA) as key regulators in melanoma. This study uses in silico analysis to explore the circRNA-miRNA-mRNA axis in melanoma progression. METHODS: We analyzed primary (n = 42)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40436810
DOI: 10.1002/jgm.70023

Genes

BRAF
ADAMTS3
CFH
COL8A1
FGF1
HMOX1
IL33
SNAI2
SYK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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