Article
The risk of a second primary cancer in PTEN Hamartoma Tumor Syndrome (PHTS).
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Oct 2025
Hendricks Linda A J, Verbeek Katja C J, Schuurs-Hoeijmakers Janneke H M, de Jong Mirjam M, Links Thera P, Brems Hilde, Aerden Mio, Brunet Joan, Lleuger-Pujol Roser, Hüneburg Robert, Aretz Stefan, Colas Chrystelle, Villy Marie-Charlotte, Woodward Emma R, Evans D Gareth, Bosch Daniëlle G M, Donze Stephany H, Foretová Lenka, Blatnik Ana, Leter Edward M, Tischkowitz Marc, Jahn Arne, de Putter Robin, Dupont Juliette, Briskemyr Siri, Steinke-Lange Verena, Baldassarri Margherita, Anastasiadou Violetta C, Irmejs Arvīds, Oliveira Carla, van der Post Rachel S, Mensenkamp Arjen R, Tesi Bianca, Mu Ninni, Benusiglio Patrick R, Gerasimenko Anna, Innella Giovanni, Turchetti Daniela, Houdayer Claude, Branchaud Maud, Høberg Vetti Hildegunn, Tveit Haavind Marianne, Balmaña Judith, Torres Maite, Genuardi Maurizio, Panfili Arianna, Jørgensen Kjersti, Mæhle Lovise, Hoogerbrugge Nicoline, Vos Janet R
Abstract excerpt
PURPOSE: Patients with PTEN Hamartoma Tumor Syndrome (PHTS) have high hereditary cancer risks for breast, endometrial, and thyroid cancer. Patients develop multiple primary cancers, but these risks remain uncertain. We aimed to provide the second primary cancer risk. METHODS: This European cohort study assessed second primary cancer risks with Kaplan-Meier analyses using data from medical files, registries and/or...
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