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Article

Longitudinal Analysis of Cancer Risk in Children and Adults With Germline PTEN Variants.

JAMA network open - 3 Apr 2023

Yehia Lamis, Plitt Gilman, Tushar Ann M, Joo Julia, Burke Carol A, Campbell Steven C, Heiden Katherine, Jin Judy, Macaron Carole, Michener Chad M, Pederson Holly J, Radhakrishnan Kadakkal, Shin Joyce, Tamburro Joan, Patil Sujata, Eng Charis

Abstract excerpt

Importance: Identifying hereditary cancer predisposition facilitates high-risk organ-specific cancer surveillance and prevention. In PTEN hamartoma tumor syndrome (PHTS), longitudinal studies remain lacking, and there are insufficient data on cancers in children and young adults, as well as individuals with neurodevelopmental disorders (NDD). Objective: To evaluate lifetime cancer risks, including second...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37093598
DOI: 10.1001/jamanetworkopen.2023.9705
PMCID: PMC10126871

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