Article
Non-serous ovarian cancer in PTEN Hamartoma Tumor Syndrome: additional evidence for increased risk.
Familial cancer - 18 Mar 2025
Schei-Andersen Ane J, Witjes Vera M, Vos Janet R, Mensenkamp Arjen R, van Altena Anne, Schieving Jolanda, Simons Michiel, Schuurs-Hoeijmakers Janneke H M, Hoogerbrugge Nicoline
Abstract excerpt
Increased hereditary cancer risk is one of the hallmarks of PTEN Hamartoma Tumor Syndrome (PHTS) which is caused by a pathogenic germline variant in PTEN. Case reports and some cohort studies have described ovarian cancer (OC) in PHTS patients. Previously, we observed an enrichment of non-serous OC in PHTS compared to sporadic cases (3% vs 1%). However, ovarian cancer is currently not considered a PHTS-related...
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