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Detection rates of multigene panel and exome testing in patients with previous negative BRCA1/2 results.

Familial cancer - 26 May 2025

Wasson Jewel L, Sprague Trinity N, Thull Darcy L, May Maureen, Vitale Kathleen E, Sanoba Shenin A, Yatsenko Alexander N, Bellissimo Daniel, Mai Phuong L

Abstract excerpt

Since panel genetic testing has become widely available, national guidelines recommend that individuals who previously underwent BRCA1/2-only testing should undergo updated testing to include other hereditary breast and ovarian cancer predisposition genes. Our study assessed the yield of additional hereditary cancer predisposition testing in patients who previously underwent negative BRCA1/2 testing....

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Source

Identifiers

PMID: 40418377
DOI: 10.1007/s10689-025-00471-x

Genes

BRCA1
ATM
MSH6
PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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