Intrathecal nivolumab and IL-2 for treatment of leptomeningeal metastases in EGFR-mutated lung adenocarcinoma.

doi:10.1016/j.lungcan.2025.108586

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Article

Intrathecal nivolumab and IL-2 for treatment of leptomeningeal metastases in EGFR-mutated lung adenocarcinoma.

Lung cancer (Amsterdam, Netherlands) - 1 Jun 2025

Ruan Zhaohui, Zeng Liang, Zhang Jin, Qin Haoyue, Huang Zhe, Yan Huan, Zhang Gao, Zhang Yongchang

Abstract excerpt

OBJECTIVES: Leptomeningeal metastasis (LM) is a serious complication of advanced non-small-cell lung cancer (NSCLC). Intrathecal administration of nivolumab or interleukin-2 (IL-2) has demonstrated efficacy in this setting. Preclinical and limited clinical evidence suggest that combining IL-2 with anti-PD1 therapy may synergistically enhance anti-tumor immunity. However, clinical data on the efficacy and safety...

Read the complete abstract on PubMed

Topics

Humans
Adenocarcinoma of Lung
Antineoplastic Combined Chemotherapy Protocols
Carcinoma, Non-Small-Cell Lung
ErbB Receptors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Injections, Spinal

Interleukin-2

Lung Neoplasms

Meningeal Neoplasms

Mutation

Nivolumab

Treatment Outcome

Source

Open in PubMed

Identifiers

PMID: 40412102
DOI: 10.1016/j.lungcan.2025.108586

Genes

EGFR
CD4
FAS

Provenance

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