Article
Functional implications of hexameric dynamics in SARS-CoV-2 Nsp15.
Protein science : a publication of the Protein Society - 1 Jun 2025
Sonowal Manashi, Ketawala Gihan, Nagaratnam Nirupa, Logeswaran Dhenugen, Basu Shibom, de Sanctis Daniele, Orlans Julien, Rose Samuel L, Jernigan Rebecca J, Hu Hao, Aguilar Jose Domingo Meza, Ranaweera Madurangi E, Zacks Michele A, Chen Julian J-L, Hansen Debra T, Schrag Lynn G, Fromme Raimund, Botha Sabine, Fromme Petra
Abstract excerpt
SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has undergone continuous evolution, leading to the emergence of variants with altered transmissibility and immune evasion. For the non-structural proteins (Nsps) of SARS-CoV-2, there are limited structural analyses of their naturally occurring mutations. Here, we identified four non-synonymous single-nucleotide polymorphisms (nsSNPs) in the Epsilon...
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