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Porcine nasal organoids to model interactions between the swine nasal microbiota and the host

22 May 2025

Abstract excerpt

BACKGROUND: Interactions between the nasal epithelium, commensal nasal microbiota, and respiratory pathogens play a key role in respiratory infections. Currently, there is a lack of experimental models to study such interactions under defined in vitro conditions. Here, we developed a porcine nasal organoid (PNO) system from nasal tissue of pigs as well as from cytological brushes. RESULTS: PNOs exhibited similar...

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PMID: 40405292
DOI: 10.1186/s40168-025-02088-9

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