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Article

Molecular Insights Into the Natural History of Anal HSIL.

Journal of medical virology - 1 May 2025

Jary Aude, van der Zee Ramon P, Jongen Vita, Ter Braak Timo J, Kim Yongsoo, Meijer Chris J L M, van Noesel Carel J M, de Vries Henry J C, van der Loeff Maarten F Schim, Steenbergen Renske D M

Abstract excerpt

Anal squamous cell carcinoma is commonly associated with human papillomavirus (HPV) infection and preceded by low- and high-grade anal lesions (LSIL; HSIL). We performed a molecular comparison on paired LSIL- and HSIL-lesions collected in a longitudinal fashion to assess their relationship. Fifty biopsies from 22 men diagnosed with LSIL at baseline (T0) who developed HSIL during follow-up (T1) were subjected to a...

Read the complete abstract on PubMed

Topics

Humans
Male
Anus Neoplasms
Middle Aged
Papillomavirus Infections
DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

Carcinoma, Squamous Cell

Aged

Biopsy

Human papillomavirus 16

DNA, Viral

Longitudinal Studies

Papillomaviridae

Genotype

Source

Open in PubMed Open full text

Identifiers

PMID: 40400293
DOI: 10.1002/jmv.70397
PMCID: PMC12096055

Provenance

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