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Gene methylation of CADM1 and MAL identified as a biomarker of high grade anal intraepithelial neoplasia

3 Mar 2022

Abstract excerpt

Human papillomavirus (HPV) is detected in up to 96% of anal squamous cell cancers, where screening programs needed. However, the best methodology is still undetermined. Host DNA methylation markers CADM1, MAL and miR124 have been identified in cervical disease, but not anal disease. Anal swabs varying by disease grade were assessed for DNA methylation of CADM1, MAL and miR124-2. Each marker was compared across...

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PMID: 35241698
DOI: 10.1038/s41598-022-07258-5

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