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Article

Laser capture microdissection as a tool to evaluate human papillomavirus genotyping and methylation as biomarkers of persistence and progression of anal lesions.

BMJ open - 26 Aug 2015

Cornall Alyssa M, Roberts Jennifer M, Molano Monica, Machalek Dorothy A, Phillips Samuel, Hillman Richard J, Grulich Andrew E, Jin Fengyi, Poynten I Mary, Templeton David J, Garland Suzanne M, Tabrizi Sepehr N

Abstract excerpt

INTRODUCTION: Anal squamous cell carcinoma is preceded by persistent infection with high-risk human papillomavirus (HPV) and the cancer precursor, high-grade squamous intraepithelial lesion (HSIL). Detection of specific HPV genotypes and HPV-related biomarkers may be an option for primary anal screening. However, more data on the natural history of HPV-related anal lesions are required. The outcomes from this...

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Identifiers

PMID: 26310402
DOI: 10.1136/bmjopen-2015-008439
PMCID: PMC4554896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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