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Article

Changes in the genetic landscape during the malignization of high grade squamous intraepithelial lesion into cervical cancer.

Current problems in cancer - 1 Oct 2020

Litviakov Nikolai V, Ibragimova M K, Tsyganov M M, Shpileva O V, Churuksaeva O N, Kolomiets L A

Abstract excerpt

In 5 patients, a change in the genetic landscape from HPV16 positive high-grade squamous intraepithelial lesion (HSIL) to squamous cervical cancer was traced, which occurred in these patients within the period from 7 months to 5 years after diagnosing HSIL. MATERIALS AND METHODS: The DNA from paraffin blocks of dysplasia tissue and the tumor that emerged afterwards was used for the study, which was analyzed using...

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PMID: 32201051
DOI: 10.1016/j.currproblcancer.2020.100567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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