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Tumor tissue-of-origin classification using miRNA-mRNA-lncRNA interaction networks and machine learning methods

6 May 2025

Abstract excerpt

Introduction MicroRNAs (miRNAs) regulate gene expression and play an important role in carcinogenesis through complex interactions with messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs). Despite their established influence on tumor progression and therapeutic resistance, the application of miRNA interaction networks for tumor tissue-of-origin (TOO) classification remains underexplored. Methods We...

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PMID: 40395370
DOI: 10.3389/fbinf.2025.1571476

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