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Article

Functional Characterization of Residues Affecting the Catalytic Activity of Glucosyltransferase from Streptococcus mutans.

The journal of physical chemistry. B - 29 May 2025

Atta Lubna, Mushtaq Mamona, Siddiqui Ali Raza, Nur-E-Alam Mohammad, Ahmed Aftab, Ul-Haq Zaheer

Abstract excerpt

Dental caries is a multifactorial, biofilm-mediated disease primarily caused by Streptococcus mutans, a key etiological agent. This bacterium secretes extracellular enzymes known as glucosyltransferases (Gtfs), also termed glucansucrases, which play a pivotal role in the synthesis of exopolysaccharides through the metabolism of dietary sucrose. These exopolysaccharides provide binding sites for the attachment and...

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PMID: 40388349
DOI: 10.1021/acs.jpcb.4c07136

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