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Transcriptomic signatures of oxytosis/ferroptosis are enriched in Alzheimer’s disease

14 May 2025

Abstract excerpt

BACKGROUND: Oxytosis/ferroptosis is a form of non-apoptotic regulated cell death characterized by specific changes in the redox balance that lead to lethal lipid peroxidation. It has been hypothesized recently that aging predisposes the brain to the activation of oxytosis/ferroptosis in Alzheimer's disease (AD), and consequently that inhibition of oxytosis/ferroptosis offers a path to develop a new class of...

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PMID: 40369584
DOI: 10.1186/s12915-025-02235-6

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