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Article

A single amino acid mutation in VP1 of coxsackievirus A6 determining efficiency of VP0 cleavage and proliferation.

Journal of virology - 17 Jun 2025

Sun Yihao, Qian ShaSha, Du Yaxin, Wu Jiahui, Rehemutula Hadireya, Meng Shengli, Wang Zejun, Guo Jing, Shen Shuo

Abstract excerpt

Coxsackievirus A6 (CV-A6) has emerged as a major pathogen associated with hand, foot, and mouth disease (HFMD), capable of infecting both children and adults. However, currently, there is no effective vaccine to prevent HFMD caused by non-EV-A71 enteroviruses. In this study, a pair of CV-A6 strains was selected from a rhabdomyosarcoma (RD)-isolated and Vero-adapted stock with a difference of 7 nucleotides in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40366174
DOI: 10.1128/jvi.00128-25
PMCID: PMC12180516

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A single amino acid mutation in VP1 of coxsackievirus A6 determining efficiency of VP0 cleavage and proliferation.PMID 40366174Read ↗

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