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Article

Genetic insight into lung neuroendocrine tumors: Notch and Wnt signaling pathways as potential targets.

Journal of translational medicine - 14 May 2025

Pecora Giulia, Mancini Camilla, Mazzilli Rossella, Zamponi Virginia, Telese Stefano, Scalera Stefano, Maugeri-Saccà Marcello, Ciuffreda Ludovica, De Nicola Francesca, Fanciulli Maurizio, La Salvia Anna, Mancini Massimiliano, Vecchione Andrea, Siciliani Alessandra, Ibrahim Mohsen, Bellavia Diana, Isidori Andrea Marcello, Faggiano Antongiulio, Mancini Rita, De Vitis Claudia

Abstract excerpt

BACKGROUND: The molecular landscape of lung neuroendocrine neoplasms is still poorly characterized, making it difficult to develop a molecular classification and personalized therapeutic approaches. Significant clinical heterogeneity of these malignancies has been highlighted among poorly differentiated histotypes and within the subgroup of well-differentiated neuroendocrine tumors (NET). Currently, the main...

Read the complete abstract on PubMed

Topics

Humans
Lung Neoplasms
Neuroendocrine Tumors
Receptors, Notch

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

DNA Copy Number Variations

Mutation

Female

Male

Middle Aged

Wnt Signaling Pathway

Aged

Exome Sequencing

Pilot Projects

Molecular Targeted Therapy

Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 40361150
DOI: 10.1186/s12967-025-06442-1
PMCID: PMC12076951

Genes

ATR
COL7A1
KDM5C
NOTCH4
PTPRS
SMO
SPEN
SPTA1
TAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

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