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Article

The impact of pre-existing immunity on the emergence of within-host immune-escape mutations in Omicron lineages.

The Journal of general virology - 1 May 2025

Ahmed Muna N, Abu Habib Ummay Salma, Abdallah Abdallah M, Emara Mohamed M, Pain Arnab, Althani Asmaa A, Nasrallah Gheyath K, Yassine Hadi M, Al-Khatib Hebah A

Abstract excerpt

The Omicron variant of SARS-CoV-2 circulating amongst highly immunized populations is anticipated to induce immunological pressures, potentially compromising existing immunity. This study investigates vaccine-induced immunity's impact on within-host diversity of Omicron variants and evaluates sub-consensus mutations at spike protein antigenic sites. Next-generation sequencing assessed the within-host diversity of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40358996
DOI: 10.1099/jgv.0.002108
PMCID: PMC12075854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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