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Indoleamine 2,3-dioxygenase can improve ovarian function in premature ovarian insufficiency via aromatic hydrocarbon receptor and regulatory T cells

12 May 2025

Abstract excerpt

BACKGROUND: Premature ovarian insufficiency (POI) is the loss of ovarian function among women <40 years of age, and immune disorders play a critical role in POI development. Indoleamine 2,3-dioxygenase (IDO) catalyzes tryptophan metabolism via the kynurenine pathway and plays a key role in preventing and treating immune-related diseases. METHODS: Human ovarian granulosa cells (hGCs) were collected via the density...

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PMID: 40358004
DOI: 10.1093/biolre/ioaf102

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