miR‐21 and Pellino‐1 Expression Profiling in Autoimmune Premature Ovarian Insufficiency

Abstract excerpt

Background . Premature ovarian insufficiency (POI) represents the hypergonadotropic hypoestrogenic symptoms that result in the loss of ovarian follicles. 5‐30% POI cases are suggested to be involved in autoimmune etiology. MicroRNA‐21 (miR‐21) plays a vital role in ovarian folliculogenesis via regulating and interacting with multiple target genes. Here, we conduct the target prediction of miR‐21, identify the...

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