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Article

A contextual genomic perspective on physical activity and its relationship to health, well being and illness.

Nature genetics - 1 Aug 2025

Galimberti Marco, Levey Daniel F, Deak Joseph D, Adhikari Keyrun, Overstreet Cassie, Gupta Priya, Nitin Rachana, Zhou Hang, Lake Nicole J, Harrington Kelly M, Djousse Luc, Davis Lea K, Gaziano J Michael, Stein Murray B, Gelernter Joel

Abstract excerpt

Physical activity (PA) is one of the most fundamental traits in the animal kingdom, has pervasive health benefits, and is genetically influenced. Using data from the Million Veteran Program, we conducted genetic analyses of leisure, work and home-time PA. For leisure, we included 189,812 individuals of European ancestry (SNP-based heritability (h2) = 0.083 ± 0.005), 27,044 of African ancestry (h2 = 0.034 ± 0.017)...

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Identifiers

PMID: 40691405
DOI: 10.1038/s41588-025-02260-9
PMCID: PMC12339386

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