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Endothelial major vault protein alleviates vascular remodeling via promoting Parkin-mediated mitophagy

10 May 2025

Abstract excerpt

Many important vascular diseases including neointimal hyperplasia and atherosclerosis are characterized by the endothelial cell (EC) injury-initiated pathological vascular remodeling. However, the endogenous regulatory mechanisms underlying it are not fully understood. The present study investigates regulatory role of major vault protein (MVP) in the pathogenesis of vascular remodeling via controlling EC injury....

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PMID: 40348769
DOI: 10.1038/s41467-025-59644-y

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