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Recent Advances in Schizophrenia Genomics and Emerging Clinical Implications.

The Psychiatric clinics of North America - 1 Jun 2025

Bigdeli Tim B, Harvey Philip D

Abstract excerpt

The conceptualization of schizophrenia has evolved from Emil Kraepelin's identification of "dementia praecox" as a distinct illness characterized by cognitive and functional deficits to the modern understanding of its complex nature. Recent research, including the "deficit syndrome," highlights enduring negative symptoms that correlate with poor functional outcomes. Genetic epidemiologic studies reveal a strong...

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PMID: 40348420
DOI: 10.1016/j.psc.2025.01.008

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