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Article

Mutant emergence timing and population immunisation status impact epidemiological dynamics.

Journal of theoretical biology - 7 Jul 2025

Reyné Bastien, Djidjou-Demasse Ramsès, Sofonea Mircea T, Alizon Samuel

Abstract excerpt

A key question in evolutionary epidemiology is to determine differences in the conditions that may allow some mutant strains to spread in a population where a resident strain is already circulating. Evolutionary invasion analyses assume that the immunity is long-lasting for previously infected individuals making it difficult to study traits such as immune escape. We relax this last assumption and allow the...

Read the complete abstract on PubMed

Topics

Humans
COVID-19
SARS-CoV-2
Mutation
Immunization
Time Factors

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Identifiers

PMID: 40348170
DOI: 10.1016/j.jtbi.2025.112140

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