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Article

Causal relationship between schizophrenia and five types of dementia: A bidirectional two-sample Mendelian randomization study.

PloS one - 1 Jan 2025

Tao Feng, Deng Shizhe, Zhuo Bifang, Liu Jingyue, Liang Xuan, Shi Jiangwei, Meng Zhihong

Abstract excerpt

BACKGROUND: Although observational research indicates an association between schizophrenia and dementia, it is unclear whether the two are causally related. In order to examine the causal relationship between schizophrenia and five types of dementia (all-cause dementia, Alzheimer's disease, vascular dementia, frontotemporal dementia, and dementia with Lewy bodies), we performed a bidirectional two-sample...

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PMID: 40338973
DOI: 10.1371/journal.pone.0322752
PMCID: PMC12061177

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