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Survival mechanism of pancreatic tumor bacteria and their ability to metabolize chemotherapy drugs

12 Aug 2025

Abstract excerpt

Pancreatic cancer (PC) remains one of the most lethal malignancies, with limited treatment efficacy. While surgical resection is the most effective option, chemotherapy with agents such as 5-fluorouracil (5-FU) and gemcitabine may improve survival. Intraductal papillary mucinous neoplasms (IPMNs) are pancreatic cystic tumors and important precursor lesions frequently detected during PC screening. Emerging...

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PMID: 40792508
DOI: 10.1128/spectrum.01820-25

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