Article
Tumor microbiome contributes to an aggressive phenotype in the basal-like subtype of pancreatic cancer.
Communications biology - 31 Aug 2021
Guo Wei, Zhang Yuchao, Guo Shiwei, Mei Zi, Liao Huiping, Dong Hang, Wu Kai, Ye Haocheng, Zhang Yuhang, Zhu Yufei, Lang Jingyu, Hu Landian, Jin Gang, Kong Xiangyin
Abstract excerpt
Despite the uniform mortality in pancreatic adenocarcinoma (PDAC), clinical disease heterogeneity exists with limited genomic differences. A highly aggressive tumor subtype termed 'basal-like' was identified to show worse outcomes and higher inflammatory responses. Here, we focus on the microbial effect in PDAC progression and present a comprehensive analysis of the tumor microbiome in different PDAC subtypes...
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