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Article

An mRNA vaccine provides effective protection against Duck Tembusu Virus infection

5 May 2025

Abstract excerpt

As an emerging flavivirus, Duck Tembusu virus (DTMUV) causes severe neurological disorder and acute egg drop syndrome in poultry. Herein, we report the development of a highly effective mRNA vaccine against DTMUV using lipid nanoparticle (LNP) delivery technology. We engineered an mRNA construct encoding the pre-membrane (prM) and envelope (E) proteins of DTMUV, with an upstream signal peptide to enhance...

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PMID: 40325031
DOI: 10.1038/s41541-025-01146-5

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