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Article

Paired molecular profiling of malignant transformation of an epidermoid cyst for potential genetic drivers: illustrative case

5 May 2025

Abstract excerpt

BACKGROUND: Malignant transformation of an intracranial epidermoid cyst (EC) into squamous cell carcinoma (SCC) is an exceedingly rare occurrence that is typically diagnosed on postoperative histology. The mechanisms underlying transformation remain poorly understood, with limited characterization of genetic changes associated with progression. OBSERVATIONS: A 55-year-old female presented with a large...

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PMID: 40324326
DOI: 10.3171/case24849

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