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Article

Identification of novel genetic susceptibility loci for thoracic and abdominal aortic aneurysms via genome-wide association study using the UK Biobank Cohort.

PloS one - 1 Jan 2021

Ashvetiya Tamara, Fan Sherry X, Chen Yi-Ju, Williams Charles H, O'Connell Jeffery R, Perry James A, Hong Charles C

Abstract excerpt

BACKGROUND: Thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA) are known to have a strong genetic component. METHODS AND RESULTS: In a genome-wide association study (GWAS) using the UK Biobank, we analyzed the genomes of 1,363 individuals with AAA compared to 27,260 age, ancestry, and sex-matched controls (1:20 case:control study design). A similar analysis was repeated for 435 individuals with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34469433
DOI: 10.1371/journal.pone.0247287
PMCID: PMC8409653

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