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Usutu virus and West Nile virus use a transcellular route of neuroinvasion across an in vitro model of the human blood–brain barrier

25 Jul 2024

Abstract excerpt

West Nile virus (WNV) leads to thousands of cases of severe neurological disease in humans each year. Usutu virus (USUV) is closely related to WNV, but rarely induces disease in humans. We hypothesised that USUV is less able to cross the blood-brain barrier (BBB) and, consequently, is less likely to infect the brain. Therefore, we developed an in vitro BBB model consisting of primary human brain microvascular...

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PMID: 40295794
DOI: 10.1038/s44298-024-00034-4

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