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Rift Valley fever virus is able to cross the human blood–brain barrier in vitro by direct infection with no deleterious effects

30 Sept 2024

Abstract excerpt

ABSTRACT Rift Valley fever (RVF) is a zoonotic arboviral disease that causes recurrent epidemics in Africa that may trigger fatal neurological disorders. However, the mechanisms of neuroinvasion by which the RVF virus (RVFV) reaches the human central nervous system (CNS) remain poorly characterized. In particular, it is not clear how RVFV is able to cross the human blood–brain barrier (hBBB), which is a...

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PMID: 39345143
DOI: 10.1128/jvi.01267-24

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