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From Dominant Assumptions to Recessive Trait: Rethinking BMP15 in Ovarian Dysfunction.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Jun 2025

Hervé Bérénice, Verebi Camille, Bonnier Marion, Jordan Pénélope, Stroe Diana, Voisin Charlotte, Hill Diane, Sarfati Cynthia, Lansiaux Maud, Terral Daniel, Bachelot Anne, Dupont Jean Michel, Christin-Maitre Sophie, Plu-Bureau Geneviève, Bienvenu Thierry

Abstract excerpt

Approximately 1% of women experience premature ovarian insufficiency (POI) before the age of 40. Genetic factors play a significant role in the development of POI. The BMP15 gene is one of the first genes involved in POI. However, the pathogenicity and the penetrance of BMP15 variants still remain unclear. A cohort of 500 patients with POI/DOR (diminished ovarian reserve) underwent next generation sequencing of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40274730
DOI: 10.1007/s43032-025-01831-9

Genes

BMP15

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