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Article

Brief antibiotic use drives human gut bacteria towards low-cost resistance.

Nature - 1 May 2025

Yaffe Eitan, Dethlefsen Les, Patankar Arati V, Gui Chen, Holmes Susan, Relman David A

Abstract excerpt

Understanding the relationship between antibiotic use and the evolution of antimicrobial resistance is vital for effective antibiotic stewardship. Yet, animal models and in vitro experiments poorly replicate real-world conditions1. To explain how resistance evolves in vivo, we exposed 60 human participants to ciprofloxacin and used longitudinal stool samples and a new computational method to assemble the genomes...

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Identifiers

PMID: 40269166
DOI: 10.1038/s41586-025-08781-x
PMCID: PMC12168174

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