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Assessing the causal effects of type 2 diabetes and obesity-related traits on COVID-19 severity.

Human genomics - 22 Apr 2025

Seo Jieun, Kim Gaeun, Park Seunghwan, Lee Aeyeon, Liang Liming, Park Taesung, Chung Wonil

Abstract excerpt

BACKGROUND: Type 2 diabetes (T2D) and obesity-related traits are highly comorbid with coronavirus disease 2019 (COVID-19), but their causal relationships with disease severity remain unclear. While recent Mendelian randomization (MR) studies suggest a causal link between obesity-related traits and COVID-19 severity, findings regarding T2D are inconsistent, particularly when adjusting for body mass index (BMI)....

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Body Mass Index
COVID-19
Mendelian Randomization Analysis
Obesity
SARS-CoV-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Severity of Illness Index

Waist Circumference

Waist-Hip Ratio

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Identifiers

PMID: 40264243
DOI: 10.1186/s40246-025-00747-4
PMCID: PMC12016339

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