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Unraveling Disease-Associated PIWI-Interacting RNAs with a Contrastive Learning Methods

23 Apr 2025

Abstract excerpt

PIWI-interacting RNAs (piRNAs) are a class of small, non-coding RNAs predominantly expressed in the germ cells of animals and play a crucial role in maintaining genomic integrity, mediating transposon suppression, and ensuring gene stability. Beyond their functions in reproductive cells, piRNAs also play roles in various human diseases, including cancer, suggesting their potential as significant biomarkers...

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PMID: 40263714
DOI: 10.1021/acs.jcim.5c00173

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