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Article

MRDPDA: A multi-Laplacian regularized deepFM model for predicting piRNA-disease associations.

Journal of cellular and molecular medicine - 1 Sept 2024

Liu Yajun, Zhang Fan, Ding Yulian, Fei Rong, Li Junhuai, Wu Fang-Xiang

Abstract excerpt

PIWI-interacting RNAs (piRNAs) are a typical class of small non-coding RNAs, which are essential for gene regulation, genome stability and so on. Accumulating studies have revealed that piRNAs have significant potential as biomarkers and therapeutic targets for a variety of diseases. However current computational methods face the challenge in effectively capturing piRNA-disease associations (PDAs) from limited...

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PMID: 39228010
DOI: 10.1111/jcmm.70046
PMCID: PMC11371490

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