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Identification and validation of robust hospital-acquired pneumonia subphenotypes associated with all-cause mortality: a multi-cohort derivation and validation.

Intensive care medicine - 1 Apr 2025

Martin Florian Pierre, Poulain Cécile, Mulier Jelle Haitsma, Motos Ana, Gourain Victor, Ogan Ismaël, Montassier Emmanuel, Launey Yoann, Lasocki Sigismond, Cinotti Raphaël, Dahyot Fizelier Claire, Ranzani Otavio, Reyes Luis Felipe, Martin-Loeches Ignacio, Derde Lennie, Torres Antoni, Cremer Olaf, Roquilly Antoine

Abstract excerpt

PURPOSE: Despite optimal antimicrobial therapy, the treatment failure rate of hospital-acquired pneumonia (HAP) routinely reaches 40% in critically ill patients. Subphenotypes have been identified within sepsis and acute respiratory distress syndrome with important predictive and possibly therapeutic implications. We derived prognosis subphenotypes for HAP and explored whether they were associated with biological...

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PMID: 40261385
DOI: 10.1007/s00134-025-07884-3

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