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Integrating machine learning models with multi-omics analysis to decipher the prognostic significance of mitotic catastrophe heterogeneity in bladder cancer

21 Apr 2025

Abstract excerpt

BACKGROUND: Mitotic catastrophe is well-known as a major pathway of endogenous tumor death, but the prognostic significance of its heterogeneity regarding bladder cancer (BLCA) remains unclear. METHODS: Our study focused on digging deeper into the TCGA and GEO databases. Through differential expression analysis as well as Weighted Gene Co-expression Network Analysis (WGCNA), we identified dysregulated mitotic...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 40259382
DOI: 10.1186/s13062-025-00650-x

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