Article
Potentially adaptive SARS-CoV-2 mutations discovered with novel spatiotemporal and explainable AI models.
Genome biology - 23 Dec 2020
Garvin Michael R, T Prates Erica, Pavicic Mirko, Jones Piet, Amos B Kirtley, Geiger Armin, Shah Manesh B, Streich Jared, Felipe Machado Gazolla Joao Gabriel, Kainer David, Cliff Ashley, Romero Jonathon, Keith Nathan, Brown James B, Jacobson Daniel
Abstract excerpt
BACKGROUND: A mechanistic understanding of the spread of SARS-CoV-2 and diligent tracking of ongoing mutagenesis are of key importance to plan robust strategies for confining its transmission. Large numbers of available sequences and their dates of transmission provide an unprecedented opportunity to analyze evolutionary adaptation in novel ways. Addition of high-resolution structural information can reveal the...
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