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Genetic associations of plasma proteins and breast cancer identify potential therapeutic drug candidates

15 Apr 2025

Abstract excerpt

To address the pressing need to improve breast cancer outcomes, we identify 9 plasma proteins with significant associations to breast cancer, namely ULK3, CSK, ASIP, TLR1 in breast cancer, ADH5, SARS2, ULK3, UBE2N in Luminal A subtype, PEX14 in Luminal B subtype. Tumor immune cell infiltration analysis and mutation phenotypes in mice further demonstrate a complex pattern of interaction between these genes and...

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PMID: 40234727
DOI: 10.1038/s42003-025-08046-3

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