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Infant RSV immunoprophylaxis changes nasal epithelial DNA methylation at 6 years of age

2 Sept 2021

Abstract excerpt

BACKGROUND: Respiratory syncytial virus (RSV) infection has been associated with childhood wheeze and asthma, and potential mechanisms include persistent epigenetic effects. METHODS: In the randomized, placebo-controlled MAKI trial, 429 preterm infants randomly received RSV immunoprophylaxis with palivizumab or placebo during their first RSV season. Children were followed until age 6 for asthma evaluation. DNA...

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PMID: 34473906
DOI: 10.1002/ppul.25643

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