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Article

Conversion to Mild Cognitive Impairment and Alzheimer's Disease Dementia Related to Apathy, APOE Genotype and Antidepressant Use.

Journal of geriatric psychiatry and neurology - 1 Nov 2025

Malik Rubina, Martinez Miguel Restrepo, So Isis, Finger Elizabeth

Abstract excerpt

ObjectiveApathy and APOE ε4 genotype are risk factors for developing Alzheimer's disease dementia (ADD). Antidepressant use is known to induce apathy. This study aimed to examine associations between APOE ε4, apathy, and antidepressant use with progression from cognitively normal (CN) to mild cognitive impairments (MCI), and MCI to ADD.MethodsParticipants aged 55-90 were recruited from the Alzheimer's Disease...

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Identifiers

PMID: 40227643
DOI: 10.1177/08919887251335002
PMCID: PMC12433532

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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