Article
Precision dosing of venlafaxine during pregnancy: a pharmacokinetics modelling approach.
The Journal of pharmacy and pharmacology - 27 Jan 2024
Alenezi Mona, Badhan Raj K S
Abstract excerpt
OBJECTIVES: Venlafaxine exposure through gestation is affected by the longitudinal changes in maternal physiology. Confounding treatment is also the impact of CYP2D6 polymorphisms affecting plasma concentrations of venlafaxine. METHODS: A pharmacokinetic modelling approach was employed to assess variations in maternal and foetal cord venlafaxine levels throughout gestation and to identify appropriate doses to...
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