Activating Mutations in the MET Kinase Domain Co-Occur With Other Driver Oncogenes and Mediate Resistance to Targeted Therapy in NSCLC.

doi:10.1016/j.jtho.2025.03.045

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Article

Activating Mutations in the MET Kinase Domain Co-Occur With Other Driver Oncogenes and Mediate Resistance to Targeted Therapy in NSCLC.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Aug 2025

Nakazawa Seshiru, Pecci Federica, Ricciuti Biagio, Gottlieb Felix H, Facchinetti Francesco, Harada Guilherme, Chen Monica F, Repetto Matteo, Giacomini Flavia, Jiang Jie, Locquet Marie-Anaïs, Makarem Maisam, Alessi Joao V, Di Federico Alessandro, Aldea Mihaela, Garbo Edoardo, Gandhi Malini M, Saini Arushi, Haradon Danielle, Bahcall Magda, Feng William W, Lee Jessica K, Schrock Alexa B, Drilon Alexander, Awad Mark M, Jänne Pasi A

Abstract excerpt

INTRODUCTION: MET tyrosine kinase domain (TKD) mutations have recently been characterized as de novo oncogenic drivers in NSCLC. Nevertheless, whether activating MET TKD mutations can confer resistance to targeted therapy in non-MET, oncogene-driven NSCLCs remains unclear. METHODS: To characterize the genomic features of tumors with MET TKD mutations in oncogene-driven NSCLC, we performed tumor genomic profiling...

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PMID: 40185329
DOI: 10.1016/j.jtho.2025.03.045

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