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Article

Oncogenic KRAS addiction states differentially influence MTH1 expression and 8-oxodGTPase activity in lung adenocarcinoma.

Redox biology - 1 May 2025

Mateo-Victoriano Beatriz, Samaranayake Govindi J, Pokharel Sheela, Sahayanathan Gracy Jenifer, Jayaraj Christina, Troccoli Clara I, Watson Dionysios C, Mohsen Michael G, Guo Yan, Kool Eric T, Rai Priyamvada

Abstract excerpt

The efficacy of strategies targeting oncogenic RAS, prevalent in lung adenocarcinoma (LUAD), is limited by rapid adaptive resistance mechanisms. These include loss of RAS addiction and hyperactivation of downstream signaling pathways, such as PI3K/AKT. We previously reported that oncogenic RAS-driven LUAD cells possess an enhanced reliance on MTH1, the mammalian 8-oxodGTPase, to prevent genomic incorporation of...

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Share to Adenocarcinoma of Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

Share to Lung Neoplasms

Share to Phosphoric Monoester Hydrolases

Share to Proto-Oncogene Proteins c-akt

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Identifiers

PMID: 40184641
DOI: 10.1016/j.redox.2025.103610
PMCID: PMC11999683

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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